Oxidative Stress Resistance and Viability of C. elegans in the Presence of Manganese through SKN-1 Protein Expression

  • Lauren Accacia Sequeira Vanderbilt University


Oxidative stress plays an imperative role in viewing how humans respond to diseases, such as diabetes and cancer, as well as in the process of aging. Through research and experimentation of Caenorhabditis elegans, scientists can study organismal and cellular aging that is analogous to that of humans. C. elegans are used as an ideal model of study due to their eukaryotic existence, as well as the relative ease of development and growth protocol. Through C. elegans, researchers can examine relevant signaling pathways, such as those that regulate metabolism, nutrition, and stress responses. As the complete genome for C. elegans has been identified, researchers known the exact cell differentiation pattern of each cell, therefore allowing for in depth study about the responses of C. elegans to different conditions and stresses. The SKN-1 protein in this species initiates development of the digestive tracts and other mesendodermal tissues during the primary stages of C. elegans development. By studying the genetic mechanisms that are rooted in C. elegans aging, humans have the opportunity to identify new human genes, as well as the pathways associated with both disease and aging in humans.

Author Biography

Lauren Accacia Sequeira, Vanderbilt University
Lauren Accacia Sequeira graduated early from Vanderbilt University in December 2008 with a Bachelors Degree through the College of Arts & Sciences. She majored in Neuroscience and intends on attending medical school in Fall 2009. She is currently working as a research assistance at biodiagnostic company in Austin, TX, and will continue to do so until beginning her medical school education. Her undergraduate research was completed over the span of two years in the Neurotoxicology branch of the Vanderbilt Neuroscience department, under the guidance of Dr. Michael Aschner. Contributions for her research that are cited throughout the paper include: Jae Hyung An et al., M. Aschner et al., R. Baumeister et al., B. Bowerman et al., K. Chan et al., J. Hayes et al., M. Hertweck et al., T. Johnson et al., A. Kobayashi et al., H. Motohashi et al., and R. Nass et al.
How to Cite
SEQUEIRA, Lauren Accacia. Oxidative Stress Resistance and Viability of C. elegans in the Presence of Manganese through SKN-1 Protein Expression. Vanderbilt Undergraduate Research Journal, [S.l.], v. 5, july 2009. ISSN 1555-788X. Available at: <http://ejournals.library.vanderbilt.edu/index.php/vurj/article/view/2849>. Date accessed: 19 june 2018. doi: https://doi.org/10.15695/vurj.v5i0.2849.
Engineering and Natural Sciences


C. elegans, oxidative stress, aging, toxicology, manganese, cellular, genetics