Oxidative Stress Resistance and Viability of C. elegans in the Presence of Manganese through SKN-1 Protein Expression
AbstractOxidative stress plays an imperative role in viewing how humans respond to diseases, such as diabetes and cancer, as well as in the process of aging. Through research and experimentation of Caenorhabditis elegans, scientists can study organismal and cellular aging that is analogous to that of humans. C. elegans are used as an ideal model of study due to their eukaryotic existence, as well as the relative ease of development and growth protocol. Through C. elegans, researchers can examine relevant signaling pathways, such as those that regulate metabolism, nutrition, and stress responses. As the complete genome for C. elegans has been identified, researchers known the exact cell differentiation pattern of each cell, therefore allowing for in depth study about the responses of C. elegans to different conditions and stresses. The SKN-1 protein in this species initiates development of the digestive tracts and other mesendodermal tissues during the primary stages of C. elegans development. By studying the genetic mechanisms that are rooted in C. elegans aging, humans have the opportunity to identify new human genes, as well as the pathways associated with both disease and aging in humans.
How to Cite
SEQUEIRA, Lauren Accacia. Oxidative Stress Resistance and Viability of C. elegans in the Presence of Manganese through SKN-1 Protein Expression. Vanderbilt Undergraduate Research Journal, [S.l.], v. 5, july 2009. ISSN 1555-788X. Available at: <http://ejournals.library.vanderbilt.edu/index.php/vurj/article/view/2849>. Date accessed: 19 june 2018. doi: https://doi.org/10.15695/vurj.v5i0.2849.
Engineering and Natural Sciences
C. elegans, oxidative stress, aging, toxicology, manganese, cellular, genetics
Copyright for articles published in this journal is retained by the authors, with first publication rights granted to Vanderbilt Undergraduate Research Journal. By virtue of their appearance in this open access journal, articles are available for wide dissemination at no cost to readers, with proper attribution, in educational and other non-commercial settings. For undergraduates jointly authoring a manuscript with a faculty member, we strongly encourage the student to discuss with the faculty mentor and the Editor if the copyright policy will constrain future publication efforts in professional journals.