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The purpose of this study is to evaluate the multiyear effectiveness of a program designed to strengthen the pipeline of Latino students into post-secondary science, technology, engineering, and mathematics (STEM) education. The program includes a suite of interventions aimed at students and families, and was implemented in a low-income school cluster with a high Latino population in metro Atlanta. Our intervention includes a high school and middle school mentoring program, STEM-focused extracurricular activities (summer camps, research and community service opportunities), and college and STEM career-focused community events for families. Results suggest that GoSTEM has a positive impact on students and families with respect to college and career awareness. The mentoring program components also increase students’ college readiness and self-regulatory skills at the high school level. The extracurricular programs support this effort by increasing students’ STEM-related content knowledge and learning, and their understanding about STEM careers for both high school and middle school students. Lessons learned are also presented to help guide other practitioners of Latino outreach programs.