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We describe a game and teachers’ experiences using it in their middle and high school science courses. The game, which is called “Luck of the Draw,” was designed to engage middle, high school, and college students in genetics and encourage critical thinking about issues, such as genetic engineering. We introduced the game to high school science teachers attending a summer workshop and asked them to describe their initial impressions of the game and how they might use it in their classes; later, during the academic year, we asked them whether they used the game in their classrooms and, if so, how well it worked. We also asked middle and high school students about their experiences playing the game. Results indicated that teachers and students enjoyed the game and identified positive outcomes, including greater engagement and critical thinking. Further, the few potential problems that teachers initially thought might be encountered appeared to occur infrequently; ways to minimize these problems are discussed.